Structure of membrane protein opens up possibilities for antibiotics

23 August 2021

Photo: MIN/UHH/Tidow

Membrane protein FoxB of the hospital pathogen P. aeruginosa.

A research team from the Department of Chemistry at Universität Hamburg has studied the membrane protein FoxB in the hospital germ "Pseudomonas aeruginosa" and found that it is involved in transporting iron from the environment into the bacteria. The results could help to carry antibiotics more specifically into the cells. The work was published in the journal Proceedings of the National Academy of Sciences (PNAS).

Reference:

Inokentijs Josts, Katharina Veith, Vincent Normant, Isabelle J. Schalk, and Henning Tidow

"Structural insights into a novel family of integral membrane siderophore reductases"

PNAS 118, No. 34 e2101952118 (2021)

DOI: 10.1073/pnas.2101952118

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